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Methadone is a prescription opioid medication used for chronic pain management and for the treatment of opioid use disorder (OUD) as part of a medically supervised medication-assisted treatment (MAT) program. Because of its strength and long half-life, methadone is classified as a Schedule II controlled substance.
Methadone works by binding to opioid receptors in the brain and spinal cord. This reduces pain signals and helps prevent withdrawal symptoms in individuals recovering from opioid dependence. Unlike shorter-acting opioids, methadone provides long-lasting stabilization without intense euphoric effects when used correctly.
Methadone may be prescribed for:
Severe chronic pain requiring continuous opioid therapy
Opioid use disorder to reduce cravings and withdrawal symptoms
Long-term pain conditions where other opioids are ineffective
For addiction treatment, methadone is typically dispensed through certified treatment programs with structured monitoring.
Methadone is available in tablet, oral liquid, and injectable forms. Dosage varies widely based on the indication and individual patient response. Because methadone accumulates in the body, careful dose adjustments and close medical supervision are essential to avoid overdose.
Common side effects: drowsiness, constipation, sweating, nausea, and dizziness
Serious risks include respiratory depression, heart rhythm disturbances, dependence, and overdose
Mixing methadone with alcohol, benzodiazepines, or other CNS depressants can be life-threatening
Regular monitoring may include ECG testing for heart rhythm safety
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