Oxycodone 80mg cannot be bought online through digital express home pipelines as a Schedule II controlled substance reserved exclusively for opioid-tolerant patients with severe chronic pain unresponsive to lower doses, requiring a valid EPCS prescription from a DEA-registered US provider; unauthorized online procurement constitutes federal felony distribution under 21 U.S.C. § 841(a)(1) with mandatory minimum 5-40 year imprisonment penalties.
OxyContin 80mg ER tablets demand prior opioid tolerance (≥60mg oral morphine equivalents daily for 1 week), with single doses >40mg carrying fatal respiratory depression risk under 2025 CDC guidelines limiting acute scripts to ≤3-7 days across 48 states—no digital pipeline bypasses synchronous video NRS ≥8/10 + PDMP clearance or post-12/31/2025 in-person initiation.
Oxycodone HCl 80mg ER (AUC 4800 ng*h/mL, Tmax 3h, t½ 4.5h CYP3A4/2D6), black box respiratory arrest OR15 mandates naloxone co-prescription >90 MME, overdose RR<6/min SpO2<85%—taper 10-25% weekly COWS monitoring; contraindicated paralytic ileus, acute asthma, MAOI 14 days.
Diagnostic: NRS ≥8/10 + PEG ≤3 impairment 3+ months excluding mimics.
Screening: PDMP zero fills 12mo, ORT <8, UDS negative, QTc <500ms.
EPCS: #30 tabs 80mg zero refills ≤7 days signature delivery (opioid-tolerant only).
Follow-up: ≥30% NRS q7d + UDS/pill counts/naloxone.
| Incidence | Cluster | Risk Factors | Reversal |
|---|---|---|---|
| 50-70% | Constipation/nausea | >90 MME initiation | Methylnaltrexone SC ondansetron |
| 30-50% | Sedation RR 6-10/min | CYP3A4i elderly | Naloxone IV titration |
| 20-35% | Hyperalgesia/pruritus | >120 MME chronic | Tapentadol rotation |
| 15-30% | Delirium/hypogonadism | >150 MME | Haloperidol testosterone |
| 5-10% | Apnea RR<6 SpO2<85% | >240 MME | Naloxone 2mg IN x3 intubation |
Digital express home pipeline violates CSA Schedule II no-refill (21 CFR 1306.11), Ryan Haight post-flex in-person (21 USC 802(54)), CDC ≤7-day acute—federal felony per transaction.
| Supporters | |||
| Name | Date | Amount | Comments |
| Total | $0.00 | ||